Rabbit anti-COP1/RFWD2 Antibody
Catalog #
COP1/RFWD2
Human
IP
Rabbit
Polyclonal
Whole IgG
between 100 and 150
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Constitutive photomorphogenic protein 1 (COP1) has been characterized in plants as a RING-finger-containing protein that functions to repress plant photomorphogenesis. In mammals, COP1 has been identified as an E3 ubiquitin ligase that negatively regulates p53 protein levels in unstressed cells. In response to DNA damage COP1 is phosphorylated by the ataxia telangiectasia mutated (ATM) protein kinase and is rapidly degraded releasing p53 to exert its tumor suppressor activities.
Alternate Names
constitutive photomorphogenesis protein 1 homolog; constitutive photomorphogenic protein 1; E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase RFWD2; hCOP1; putative ubiquitin ligase COP1; RFWD2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; RING finger and WD repeat domain protein 2; RING finger protein 200; RING-type E3 ubiquitin transferase RFWD2; RNF200
Applications