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In-Depth with CD137

In-Depth with CD137

Contributed by Aliyah Weinstein, Ph.D.


CD137, also known as 4-1BB, ILA, and TNFRSF9, is a member of the TNF family that was originally identified through genetic screens as being expressed on activated T cells. CD137 is expressed on transitional CD45RA+ CD45RO+ T cells and activated CD8+ and CD4+ T cells. It can be used as a marker for CD8+ T cells that are antigen-experienced. CD137 can also be expressed on dendritic cells, where ligation promotes cell survival and activation, and increases the duration of contact between dendritic cells and T cells