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CAR-T cells for the treatment of blood and solid tumors

CAR-T Cells for the Treatment of Blood and Solid Tumors

Contributed by Aliyah Weinstein, Ph.D.


The development of CAR-T cells began in the late 1980s-1990s and the technologies that ultimately led to their creation were first developed by immunologists Michel Sadelain and Zelig Eshhar. At the time the first T cell engineering was taking place, most scientists did not believe that T cells would have much efficacy in the fight against cancer. Little could they have predicted that two decades later, CAR-T cells would be an FDA-approved treatment for adult and childhood cancer.




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