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Detection of human hSET1 (red) in FFPE ovarian carcinoma by IHC-IF. Antibody: Rabbit anti-hSET1 recombinant monoclonal [BLR024E] (A700-024). Secondary:DyLight® 594-conjugated goat anti-rabbit IgG (A120-201D4). Counterstain: DAPI (blue).

Genome stability and Chromosome Segregation: a Unique SET of Functions

Contributed by Aliyah Weinstein, Ph.D.

 

hSET1, encoded by gene SETD1A, and also known as MLL in humans, is a lysine methyltransferase. hSET1 functions as a subunit of the histone H3K4 methyltransferase complex and is most functional within the COMPASS complex.

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