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Detection of BRC1 in FFPE human breast carcinoma by IHC

Molecular Abnormalities in Breast Cancer

Contributed by Allison A. Curley, Ph.D.


Recent findings have suggested additional molecular targets for drug development. Next generation sequencing studies from almost 900 breast cancers have identified hundreds of mutations whose corresponding protein activity falls into one of two categories: activation of the PI3K/AKT pathway and repression of the JUN/MAPK pathway.