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Epithelial–mesenchymal Transition

Epithelial–mesenchymal Transition

Contributed by Jane Naberhuis, Ph.D.


The ability of epithelial cells to downregulate their epithelial characteristics and acquire a mesenchymal phenotype was initially described in the 1980s. This phenomenon was originally terms “epithelial to mesenchymal transformation” but has since become known as “epithelial-mesenchymal transition” (EMT) in order to reflect the reversable nature of the process as well as to distinguish it from neoplastic transformation.




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