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CD247/CD3Z: The Gatekeeper of T-cell Activation

CD247/CD3Z: The Gatekeeper of T-cell Activation

Contributed by Craig Vollert, Ph.D.

 

Given the role of CD247/CD3Z in T-cell activation, it’s not surprising that it may also be an important biomarker for evaluating the immune status of patients with diseases characterized by chronic inflammation. During chronic inflammation T-cell activation is suppressed, which is associated with the downregulation of only CD247/CD3Z while the remaining components of the TCR-CD3 complex are unaffected.

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