The vitamin D3 receptor (VDR) is a nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of VDR are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in the VDR gene are associated with type II vitamin D-resistant rickets [taken from NCBI Entrez Gene (Gene ID: 7421)].
1,25-dihydroxyvitamin D3 receptor•
nuclear receptor subfamily 1 group I member 1•
protein phosphatase 1, regulatory subunit 163•
vitamin D nuclear receptor variant 1•
vitamin D receptor•