TDP43 Antibody

Tar DNA-binding protein 43 (TDP43) is a DNA and RNA-binding protein which regulates transcription and splicing. It is involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TDP43 may also be involved in microRNA biogenesis, apoptosis and cell division. TDP43 can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Also, TDP43 stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13148].
TARDBP
TAR DNA binding protein
TAR DNA-binding protein 43
:  ALS10 TAR DNA-binding protein-43 TDP-43
Product
Specifications
Ordering Information
Human, Mouse
WB, IP, IHC
Between 150 and 200
$339
$229
$99
Human, Mouse
WB, IP, IHC
Between 250 and 300
$339
$229
$99
Human, Mouse
WB, IP, IHC
Includes: 1 each of A303-223A and A303-224A
$472
Includes: 1 each of A303-223A and A303-224A