TAB182 Antibody

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.
TNKS1BP1
tankyrase 1 binding protein 1
182 kDa tankyrase-1-binding protein
:  FLJ45975 KIAA1741 TAB182 tankyrase 1 binding protein 1, 182kDa tankyrase 1-binding protein of 182 kDa testis secretory sperm-binding protein Li 206a
Product
Specifications
Ordering Information
Human
WB, IP
Between 200 and 250
$339
$229
$99
Human
WB, IP
Between 350 and 400
$339
$229
$99
Human
WB, IP
Between 1679 and 1729
$339
$229
$99
Human
WB, IP
Includes: 1 each of A301-437A, A301-438A and A301-439A
$707
Includes: 1 each of A301-437A, A301-438A and A301-439A