SuFu Antibody

Suppressor of fused (SuFu) is a negative regulator of the hedgehog and beta-catenin signaling pathway. It down-regulates GLI1-mediated transactivation of target genes and is part of a corepressor complex that acts on DNA-bound GLI1. SuFu may also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Additionally, SuFu sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UMX1].
SUFU
SUFU negative regulator of hedgehog signaling
Suppressor of fused homolog
:  PRO1280 SUFUH SUFUXL suppressor of fused homolog (Drosophila)
Product
Specifications
Ordering Information
Human
IP
Between 325 and 375
$339
$99
Human, Mouse
WB, IP
Between 434 and 484
$339
$229
$99
Human, Mouse
WB, IP
Includes: 1 each of A302-334A and A302-335A
$472
Includes: 1 each of A302-334A and A302-335A