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Search Results for "Sequestosome-1"

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nf-yc (1)
nf1 (1)
nf110 (1)
nf45 (1)
nfat1 (1)
nitrated ldl (1)
npl4 (1)
occludin (1)
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ox40l/tnfsf4 (1)
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p53 (1)
p73 (1)
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pdk1 (1)
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pgc-1 (1)
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plc-gamma 1 (1)
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ppme1/pme-1 (1)
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prdm1/blimp-1 (1)
prefoldin 1 (1)
psf3 (1)
psmb8/lmp7 (1)
ptbp3/rod1 (1)
qki (1)
rabbit light chain (1)
rabbit whole serum (1)
rad17 phospho (s645) (1)
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sars-cov-2 spike rbd (1)
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shank3 (1)
sheep albumin (1)
sheep igg (1)
sheep igg heavy chain (1)
sheep igg-fab fragment (1)
slitrk5 (1)
slug (1)
smad2 (1)
smad3 (1)
smad4 (1)
smc1 phospho (s957) (1)
smg7 (1)
sodium potassium atpase alpha-1 (1)
srbd1 (1)
srebp2 (1)
stat1 (1)
stat3 phospho (s727) (1)
stat5a (1)
stat5b (1)
stat6 (1)
streptavidin (1)
suv39h1 (1)
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syne1/cpg2/nesprin 1 (1)
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Rabbit anti-Sequestosome-1 Antibody
Bethyl Laboratories® Catalog # A302-857A A302-857A-T

Validated

Rabbit anti-Sequestosome-1 Antibody

Validation Performed

All Bethyl Laboratories® antibodies are validated to meet our strict performance standards.

Learn more about the validation performed

Documents (4) Citations ()

Target: Sequestosome-1

Reactivity: Human, Mouse

Applications:

Host: Rabbit

Clonality: Polyclonal

Conjugate:

Purity:

2 Figures

parentCodeBETHYL-A302-857

Bulk Request

For ordering information, see our International Distributors

Distributors

Product has been discontinued
Rabbit anti-Sequestosome-1 Antibody
Bethyl Laboratories® Catalog # A302-856A-T A302-856A

Validated

Rabbit anti-Sequestosome-1 Antibody

Validation Performed

All Bethyl Laboratories® antibodies are validated to meet our strict performance standards.

Learn more about the validation performed

Documents (5) Citations ()

Target: Sequestosome-1

Reactivity: Human

Applications:

Host: Rabbit

Clonality: Polyclonal

Conjugate:

Purity:

2 Figures

parentCodeBETHYL-A302-856

Bulk Request

For ordering information, see our International Distributors

Distributors

Product has been discontinued
Rabbit anti-Sequestosome-1 Antibody
Bethyl Laboratories® Catalog # A302-855A-T A302-855A

Validated

Rabbit anti-Sequestosome-1 Antibody

Validation Performed

All Bethyl Laboratories® antibodies are validated to meet our strict performance standards.

Learn more about the validation performed

Documents (5) Citations ()

Target: Sequestosome-1

Reactivity: Human, Mouse

Applications:

Host: Rabbit

Clonality: Polyclonal

Conjugate:

Purity:

3 Figures

parentCodeBETHYL-A302-855

Bulk Request

For ordering information, see our International Distributors

Distributors

Product has been discontinued

Programmed Cell Death-1 (PD-1)
Aliyah Weinstein, Ph.D.

Article

Programmed cell death-1 (PD-1) is an immune checkpoint molecule that belongs to the CD28 family, which also includes CTLA-4. PD-1 is expressed on T cells and functions as a negative regulator of helper and effector T cell activity. Its ligands, PD-L1 and PD-L2, are members of the B7 family and are expressed by antigen presenting cells as well as tissue type-specific cells throughout the body and cancer cells. Binding of PD-1 to its ligands activates an intracellular signaling cascade that results in the dephosphorylation of the T cell receptor or of CD28¹, and the consequent reduction in T cell activity. In healthy individuals, this pathway tunes the immune system to protect against autoimmunity by suppressing effector T cells and promoting the activity of regulatory T cells (Tregs)^{2, 3}.
An Introduction to Multiplex Immunohistochemistry - Part 1 of 4
Jane Naberhuis, Ph.D.

Article

With the advancement of immunotherapeutics, the urge to understand the tumor microenvironment has never been more pressing. Immunohistochemistry is a powerful tool used to examine protein expression, distribution, and activation in situ. Antibodies specific to an antigen of interest are used to detect the antigen in thin sections of flash frozen or formalin-fixed paraffin-embedded tissue. Visualization of the antigen is achieved using either an enzymatic reaction that induces chromogen precipitation at the site of antibody-antigen binding, or fluorescent reporters. Fluorescent reporters may be directly conjugated to the primary antibody used to detect the antigen of interest (direct immunofluorescence), or may be attached to a secondary antibody that detects the species-specific primary antibody (indirect immunofluorescence). The latter is more common, as it achieves more sensitive antigen detection.

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