Separase is a specific endopeptidase that is responsible for cleaving the SCC1-RAD21 subunit of the cohesin complex at the onset of anaphase. Disruption of the cohesin complex by separase results in sister chromatid separation so that cytokinesis can proceed.
caspase-like protein ESPL1•
extra spindle pole bodies 1, separase•
extra spindle pole bodies homolog 1•
extra spindle poles like 1•
extra spindle poles-like 1 protein•
separin, cysteine protease•