SUZ12 Antibody

SUZ12 (suppressor of zeste 12) is the human homolog of the drosophila SUZ12 gene. SUZ12 is a Polycomb group (PcG) protein and a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. A chromosomal aberration, t(7;17)(p15;q21), involving SUZ12 and JAZF1 may be a cause of endometrial stromal tumors. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15022].
SUZ12
SUZ12 polycomb repressive complex 2 subunit
Polycomb protein SUZ12
:  chET 9 protein CHET9 chromatin precipitated E2F target 9 protein JJAZ1 joined to JAZF1 protein KIAA0160 suppressor of zeste 12 homolog (Drosophila) suppressor of zeste 12 protein homolog
Product
Specifications
Ordering Information
Human, Mouse
WB, IP
Between 689 and 739
$339
$229
$99