STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down’s syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53.
carboxy terminus of Hsp70-interacting protein•
CLL-associated antigen KW-8•
heat shock protein A binding protein 2 (c-terminal)•
serologically defined colon cancer antigen 7•
STIP1 homology and U box-containing protein 1•
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase•