SMG1 Antibody

SMG1 is a PIKK (phosphoinositide 3-kinase related kinases) protein kinase that plays a key role in RNA surveillance via nonsense-mediated mRNA decay (NMD). SMG1 phosphorylates Upf1, a factor that possesses RNA helicase activity and is also central to NMD. SMG1 and UPF-1 have been shown to exist in a complex with the translation termination release factors eRF3, and eRF1. This complex has been termed SURF and associates with the exon junction complex (EJC) to function in the recognition of premature termination codons in aberrant RNAs to trigger NMD.
SMG1
SMG1, nonsense mediated mRNA decay associated PI3K related kinase
Serine/threonine-protein kinase SMG1
:  61E3.4 ATX hSMG-1 KIAA0421 lambda/iota protein kinase C-interacting protein lambda-interacting protein LIP phosphatidylinositol 3-kinase-related kinase PI-3-kinase-related kinase SMG-1 SMG-1 smg-1 homolog, phosphatidylinositol 3-kinase-related kinase smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) SMG1 phosphatidylinositol 3-kinase-related kinase More... Less...
Product
Specifications
Ordering Information
Human
WB
Between 1625 and 1675
$339
$229
$99
Human
WB, IP, IHC
Between 2925 and 2975
$339
Human
WB, IP, PLA
Between 1250 and 1300
$339
Human
WB, IP, IHC, PLA
Includes: 1 each of A300-393A, A300-394A and A301-535A
$707
Includes: 1 each of A300-393A, A300-394A and A301-535A
Human
IHC
Between 2925 and 2975
$360
$99