RPRD1B (regulation of nuclear pre-mRNA domain containing 1B) Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. RPRD1B is a transcriptional regulator that promotes cell proliferation and enhances the transcription of a number of cell cycle-related genes including CCND1, CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NQG5].
Regulation of nuclear pre-mRNA domain-containing protein 1B
cell cycle-related and expression-elevated protein in tumor•
cell-cycle related and expression-elevated protein in tumor•
chromosome 20 open reading frame 77•