Pc2 (polycomb 2 homolog) is also known as CBX4. Pc2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is a component of the Polycomb group (PcG) multiprotein complex, PRC1 (polycomb repressive complex), a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG-PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00257].
chromobox homolog 4•
chromobox homolog 4 (Drosophila Pc class)•
chromobox homolog 4 (Pc class homolog, Drosophila)•
chromobox protein homolog 4•
chromobox-like protein 4•
NS5ATP1-binding protein 16•
Pc class 2 homolog•
Pc class 2 homolog (Drosophila)•
polycomb 2 homolog•More...Less...