Due to inclement weather, Bethyl will be closed Tuesday, January 16 and re-open Wednesday, January 17th at noon. Orders will not be processed until Bethyl re-opens. This is a developing weather situation and may continue to change. Thank you!
Progesterone-induced blocking factor (PIBF) was originally discovered as a progesterone-induced protein that mediates the immunological effects of progesterone. PIBF is produced in PR-positive lymphocytes in healthy pregnant woman. A decreased percentage of PIBF-positive lymphocytes in pregnant woman is associated with premature pregnancy termination. PIBF appears to exert its immunomodulatory and anti-abortive effects by altering cytokine production and regulating natural killer (NK) cell activity.