PHD3 Antibody

PHD3 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
egl-9 family hypoxia inducible factor 3
Egl nine homolog 3
:  EGL nine (C.elegans) homolog 3 egl nine homolog 3 (C. elegans) egl nine-like protein 3 isoform egl-9 family hypoxia-inducible factor 3 HIF prolyl hydroxylase 3 HIFP4H3 HIFPH3 HIF-PH3 HIF-prolyl hydroxylase 3 HPH-1 HPH-3 hypoxia-inducible factor prolyl hydroxylase 3 PHD3 prolyl hydroxylase domain-containing protein 3 More... Less...
Ordering Information
Human, Mouse
Between 50 and 100