Defects in the Midline-1 (MID1) gene are the cause of Opitz syndrome, an X-linked recessive disorder characterized by developmental defects. MID1 is a microtubule-associated protein (MAP) with E3 ubiquitin ligase activity. MID1 has been shown to target protein phosphatases 2A (PP2Ac) on microtubules for degradation. MID1 association with PP2A has been proposed to regulate microtubule stabilization for cellular processes such as cell division and migration.
midline 1 RING finger protein•
putative transcription factor XPRF•
RING finger protein 59•
RING finger protein Midline-1•
tripartite motif protein TRIM18•
tripartite motif-containing protein 18•
zinc finger on X and Y, mouse, homolog of•