MAML2 Antibody

There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.
MAML2
mastermind like transcriptional coactivator 2
Mastermind-like protein 2
:  KIAA1819 MAM2 mam-2 MAM3 MAM-3 mastermind (Drosophila)-like 2 mastermind-like 2 mastermind-like 2 (Drosophila) mastermind-like transcriptional coactivator 2 MLL-MAML2
Product
Specifications
Ordering Information
Human
IP
Between 250 and 300
$339
$99
Human, Mouse
WB, IP, IHC
Between 1100 and C-term
$339
$229
$99
Human, Mouse
WB, IP, IHC
Includes: 1 each of A300-681A and A300-682A
$472
Includes: 1 each of A300-681A and A300-682A
Human
IHC, IF
Between 1100 and C-term
$360
$99