As part of the Ragulator complex, LAMTOR1 is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. LAMTOR1 is activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. It is also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. It may also play a role in RHOA activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6IAA8].
chromosome 11 open reading frame 59•
late endosomal/lysosomal adaptor and MAPK and MTOR activator 1•
lipid raft adaptor protein p18•
p27kip1 releasing factor from RhoA•
p27Kip1-releasing factor from RhoA•
protein associated with DRMs and endosomes•
ragulator complex protein PDRO•
RhoA activator C11orf59•More...Less...