Ras-GAP SH3 domain binding protein (G3BP2) contains an RNA recognition motif (RRM) and an N-terminal nuclear transport factor 2-like (NTF2-like) domain. The G3BP family of proteins have been shown to function downstream of Ras and play a role in RNA metabolism, signal transduction, and proliferation.G3BP2 can interact with IkappaBalpha and IkappaBalpha/NFkappaB complexes. In this complex G3B2 is proposed to play a role in regulating the nucleocytoplasmic localization of NFkappaB as well as its activity.
GAP SH3 domain-binding protein 2•
GTPase activating protein (SH3 domain) binding protein 2•
ras GTPase-activating protein-binding protein 2•
Ras-GTPase activating protein SH3 domain-binding protein 2•