FLRF/RNF41 Antibody

FLRF/RNF41 is also known as the E3 ubiquitin-protein ligase NRDP1. FLRF/RNF41 is responsible for the ubiquitination and proteasomal degradation of the EGF (epidermal growth factor) receptor family member, ErbB3/HER3. The overexpression of FLRF/RNF41 results in a decrease of ErbB3 and inhibition of breast cancer cell growth while decreased levels of FLRF/RNF41 are inversely correlated with ErbB3 levels in primary human breast cancer tissue. FLRF/RNF41 has also been shown to catalyze the degradation of BRUCE/apollon, an inhibitor of apoptosis protein (IAP).
RNF41
ring finger protein 41
E3 ubiquitin-protein ligase NRDP1
:  fetal liver ring finger FLRF neuregulin receptor degradation protein-1 NRDP1 RING finger protein 41 ring finger protein 41, E3 ubiquitin protein ligase SBBI03
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