ErbB2 Antibody

ErbB2 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor; EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ErbB2 receptor is the only member that does not interact with a ligand, but instead functions as a heterodimeric partner to coordinate signals from other ligand bound ErbB receptors. Amplification and/or overexpression of ErbB2 have been reported in many cancers.
ERBB2
erb-b2 receptor tyrosine kinase 2
Receptor tyrosine-protein kinase erbB-2
:  CD antigen CD340 CD340 c-erb B2/neu protein HER2 HER-2 HER-2/neu herstatin human epidermal growth factor receptor 2 metastatic lymph node gene 19 protein MLN 19 NEU neuro/glioblastoma derived oncogene homolog neuroblastoma/glioblastoma derived oncogene homolog NGL p185erbB2 proto-oncogene c-ErbB-2 proto-oncogene Neu TKR1 tyrosine kinase-type cell surface receptor HER2 More... Less...
Product
Specifications
Ordering Information
Human
WB, IP, IHC-P
Between 975 and 1025
$339
Human
WB, IP, IHC-P
Between 1200 and 1250
$339
Human
WB, IP, IHC-P, PLA
Between 1200 and C-term
$339
Human
WB, IP, IHC-P, PLA
Includes: 1 each of A300-621A, A300-622A and A300-623A
$707
Includes: 1 each of A300-621A, A300-622A and A300-623A
Human
IHC-P, IF
Between 1200 and C-term
$360
$99