EYA2 (eyes absent homolog 2) functions as a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX. EYA2 promotes efficient DNA repair by dephosphorylating H2AX and promoting the recruitment of DNA repair complexes containing MDC1. EYA2 coactivates SIX1. Together with SIX1 and DACH2 EYA2 seems to be involved in myogenesis. EYA2 may be involved in development of the eye [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00167].