Dorfin is an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Dorfin specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.uniprot.org/uniprot/Q9NV58].
double ring-finger protein•
E3 ubiquitin-protein ligase RNF19A•
protein p38 interacting with transcription factor Sp1•
ring finger protein 19•
RING finger protein 19A•
ring finger protein 19A, E3 ubiquitin protein ligase•
ring-IBR-ring domain containing protein Dorfin•