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Desmoplakin Antibody

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in DSP, the gene encoding desmoplakin, are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus [taken from NCBI Entrez Gene (Gene ID: 1832)].
DSP
desmoplakin
Desmoplakin
:  250/210 kDa paraneoplastic pemphigus antigen DCWHKTA desmoplakin (DPI, DPII) DP DPI DPII KPPS2 PPKS2
Product
Specifications
Ordering Information
Human
WB, IP
Between 1600 and 1650
$339
$229
$99
Human
IP, IHC
Between 1900 and 1950
$339
$99
Human
WB, IP, IHC
Includes: 1 each of A303-355A and A303-356A
$472
Includes: 1 each of A303-355A and A303-356A