DIS3L2 Antibody

DIS3L2 is a 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IYB7].
DIS3L2
DIS3 like 3'-5' exoribonuclease 2
DIS3-like exonuclease 2
:  DIS3 mitotic control homolog-like 2 DIS3-like exonuclease 2 FAM6A family with sequence similarity 6, member A hDIS3L2 PRLMNS
Product
Specifications
Ordering Information
Human
WB
between 475 and 525
$229
$99