DDX1 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX1 has been found to associate with factors involved in 3’-end cleavage and polyadenylation of pre-mRNAs.
DEAD (Asp-Glu-Ala-Asp) box helicase 1•
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1•
DEAD box polypeptide 1•
DEAD box protein 1•
DEAD box protein retinoblastoma•
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1•