COBRA1 Antibody

COBRA1 (Cofactor of BRCA1) is also known as NELFB (negative elongation factor E). NELFB is one of four subunits that make up the NELF transcription elongation factor. The four subunits of NELF are NELF A (WHSC2), NELFB, either NELFC or NELFD, and NELFE. NELF, along with DRB sensitivity-inducing factor (DSIF), functions to cause transcriptional pausing of RNA polymerase II. COBRA1 was originally identified in a yeast two-hybrid screen of a human ovary cDNA library using the BRCA COOH terminus repeat, BRCT1, as the bait protein. In this study, COBRA1 was found to be involved in BRCT1-mediated chromatin remodeling. COBRA1 has also been found to interact with several nuclear receptors such as ERalpha and androgen receptor to modulate their transcriptional activity.
NELFB
negative elongation factor complex member B
Negative elongation factor B
:  COBRA1 cofactor of BRCA1 KIAA1182 negative elongation factor protein B NELF-B
Product
Specifications
Ordering Information
Human
WB, IP
Between 25 and 75
$339
$229
$99
Human
WB, IP, IHC
Between 530 and 580
$339
$229
$99
Human
WB, IP, IHC
Includes: 1 each of A301-911A and A301-912A
$472
Includes: 1 each of A301-911A and A301-912A
Human
IHC, IF
Between 530 and 580
$360
$99