CIZ1 Antibody

CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.
CIZ1
CDKN1A interacting zinc finger protein 1
Cip1-interacting zinc finger protein
:  CDKN1A-interacting zinc finger protein 1 LSFR1 NP94 nuclear protein NP94 zinc finger protein 356 ZNF356
Product
Specifications
Ordering Information
Human
WB, IP
Between 325 and 375
$339
$229
$99
Human
WB, IP
Between 848 and 898
$339
$229
$99
Human
WB, IP
Includes: 1 each of A301-496A and A301-497A
$472
Includes: 1 each of A301-496A and A301-497A