Cell division protein kinase 6 is a Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation. CDK6 interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. It is involved in initiation and maintenance of cell cycle exit during cell differentiation. Although, it prevents cell proliferation and regulates negatively cell differentiation, it is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). it is also essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. It may play a role in the centrosome organization during the cell cycle phases (PubMed:23918663) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q00534].