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CD45RO Antibody

CD45RO is also known as protein tyrosine phosphatase receptor type C (PTPRC). It is a protein tyrosine phosphatase required for T-cell activation through the antigen receptor. CD45RO acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, CD45RO recruits and dephosphorylates SKAP1 and FYN. It also dephosphorylates LYN, and thereby modulates LYN activity (By similarity)[taken from UniProtKB (Entry: P08575)].
protein tyrosine phosphatase, receptor type C
Receptor-type tyrosine-protein phosphatase C
:  B220 CD antigen CD45 CD45 CD45 antigen CD45R GP180 LCA L-CA Leukocyte common antigen LY5 protein tyrosine phosphatase, receptor type, c polypeptide receptor-type tyrosine-protein phosphatase C T200 T200 glycoprotein T200 leukocyte common antigen
Ordering Information
Cultured T-cells from an IL-2-dependent T-cell line (CA1)