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BRCC36 Antibody

BRCA1/BRCA2-containing complex subunit 36 (BRCC36) is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. BRCC36 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, BRCC36 specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P46736].
BRCC3
BRCA1/BRCA2-containing complex subunit 3
Lys-63-specific deubiquitinase BRCC36
:  BRCA1/BRCA2-containing complex subunit 3 BRCA1/BRCA2-containing complex subunit 36 BRCA1-A complex subunit BRCC36 BRCC36 BRISC complex subunit BRCC36 C6.1A CXorf53 lys-63-specific deubiquitinase BRCC36
Product
Specifications
Ordering Information
Human, Mouse
WB, IP, IHC
between 266 and 316
$339
$229
$99
Human
IHC
Between 266 and 316
$360
$99