Bethyl will be closed Monday, May 28th in observance of Memorial Day and will resume normal business hours on Tuesday, May 29th. Thank you!

BRCC36 Antibody

BRCA1/BRCA2-containing complex subunit 36 (BRCC36) is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. BRCC36 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, BRCC36 specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) [taken from the Universal Protein Resource (UniProt)].
BRCA1/BRCA2-containing complex subunit 3
Lys-63-specific deubiquitinase BRCC36
:  BRCA1/BRCA2-containing complex subunit 3 BRCA1/BRCA2-containing complex subunit 36 BRCA1/BRCA2-containing complex, subunit 3 BRCA1-A complex subunit BRCC36 BRCC36 BRISC complex subunit BRCC36 C6.1A chromosome X open reading frame 53 CXorf53 Lys-63-specific deubiquitinase More... Less...
Ordering Information
Human, Mouse
Between 266 and 316
Between 266 and 316