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Alsin Antibody

Alsin contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. Alsin localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in the gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis [taken from NCBI Entrez Gene (Gene ID: 57679)].
ALS2, alsin Rho guanine nucleotide exchange factor
:  ALS2CR6 alsin ALSJ amyotrophic lateral sclerosis 2 (juvenile) amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein amyotrophic lateral sclerosis 2 protein IAHSP PLSJ
Ordering Information
Human, Mouse
Between 1250 and 1300