Amyloid beta A4 precursor protein-binding family A member 3 (APBA3) may modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. APBA3 may enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O96018].