AF4 is a member of the AF4/LAF4/FMR2 (ALF) family of transcription cofactors. It has been identified as part of a translocation [t(4:11)(q21;q23)] found in patients with acute leukemia involving MLL/HRX. AF4 functions as a cofactor of transcriptional elongation and chromatin remodeling.
AF4/FMR2 family member 1•
ALL1-fused gene from chromosome 4 protein•
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2•
pre-B-cell monocytic leukemia partner 1•