Bethyl will be closed on Thursday, July 4 and Friday, July 5 in observation of the 4th of July holiday. We will re-open Monday, July 8.

TBC1D23 Antibody

TBC1D23 is a putative Rab GTPase-activating protein which plays a role in vesicular trafficking and is involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NUY8].
TBC1D23
TBC1 domain family member 23
TBC1 domain family member 23
:  HCV non-structural protein 4A-transactivated protein 1 HCV nonstructural protein 4A-transactivated protein 1 NS4ATP1 PCH11 TBC1 domain family member 23
Product
Specifications
Ordering Information
Human
WB, IP
between 525 and 575
$229
$99