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RanBP16 Antibody

RanBP16 mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. RanBP16 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UIA9].
XPO7
exportin 7
Exportin-7
:  EXP7 exportin-7 RAN binding protein 16 Ran-binding protein 16 RANBP16
Product
Specifications
Ordering Information
Human, Mouse
WB, IP
between 1 and 50
$229
$99