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CNOT1 Antibody

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. [taken from NCBI Entrez Gene (Gene ID: 23019)]. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/A5YKK6].
CNOT1
CCR4-NOT transcription complex subunit 1
CCR4-NOT transcription complex subunit 1
:  AD-005 adrenal gland protein AD-005 CCR4-associated factor 1 CCR4-NOT transcription complex subunit 1 CDC39 hNOT1 negative regulator of transcription subunit 1 homolog NOT1 NOT1 (negative regulator of transcription 1, yeast) homolog NOT1H
Product
Specifications
Ordering Information
Human, Mouse
WB, IP
between 1400 and 1450
$229
$99