CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 also serves as cell surface receptor for the cytokine MIF. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P04233].
HLA class II histocompatibility antigen gamma chain
:
CD antigen CD74•
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)•
CD74 molecule, major histocompatibility complex, class II invariant chain•
DHLAG•
gamma chain of class II antigens•
HLA class II histocompatibility antigen gamma chain•
HLADG•
HLA-DR antigens-associated invariant chain•
HLA-DR-gamma•
Ia antigen-associated invariant chain•
Ia-associated invariant chain•
Ia-GAMMA•
II•
MHC HLA-DR gamma chain•
p33•More...Less...
![CD74 Monoclonal Antibody, Purified [LN2]](/product/thumb/CD74-Monoclonal-Antibody-IHC-Bethyl-Laboratories-A500-023A-1.jpg)