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CD45 Antibody

CD45 is a protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. CD45 acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, CD45 recruits and dephosphorylates SKAP1 and FYN [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P08575].
PTPRC
protein tyrosine phosphatase, receptor type C
Receptor-type tyrosine-protein phosphatase C
:  B220 CD antigen CD45 CD45 CD45 antigen CD45R GP180 LCA L-CA Leukocyte common antigen LY5 protein tyrosine phosphatase, receptor type, C protein tyrosine phosphatase, receptor type, c polypeptide T200 T200 glycoprotein T200 leukocyte common antigen
Product
Specifications
Ordering Information
Human
WB, IP, IHC-P, ICC, IF
Between 1254 to 1304
$339
$229
$99
Human, Mouse
WB, IP, IHC-P, ICC
between 1254 to 1304
$229
$99