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ANKRD13A is a ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IZ07].
