Nuclear factor of activated T cells 1(NFAT1) is a member of the NFAT family of transcription factors which includes NFAT1 (NFATp/NFATc2), NFAT2 (NFATc/NFATc1), NFAT3 (NFATc4), and NFAT4 (NFATc3/NFATx). Different members of the NFAT family are expressed in a distinct but overlapping set of cell types. NFAT1 plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. NFAT1 is a member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFAT1 and an inducible nuclear component NFAT2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13469].
