NACC2/BTBD14A functions as a transcriptional repressor through its association with the NuRD complex. NACC2/BTBD14A recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96BF6].
BEN domain containing 9•
BTB (POZ) domain containing 14A•
BTB/POZ domain-containing protein 14A•
NACC family member 2, BEN and BTB (POZ) domain containing•
repressor with BTB domain and BEN domain•
transcription repressor with a BTB domain and a BEN domain•More...Less...