MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NWV8].
BRCA1-A complex subunit MERIT40•
chromosome 19 open reading frame 62•
Mediator of Rap80 Interactions and Targeting 40 kD•
mediator of Rap80 interactions and targeting 40 kDa•
mediator of RAP80 interactions and targeting subunit of 40 kDa•
new component of the BRCA1 A complex•
new component of the BRCA1-A complex•
new component of the BRCAA1 A complex•More...Less...