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BRSK1 Antibody

Brain-selective kinase (BRSK1) is a serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. BRSK1 phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, BRSK1 acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-579'. It also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, BRSK1 localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. BRSK1 also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. BRSK1 is involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C [taken from the Universal Protein Resource (UniProt)].
BR serine/threonine kinase 1
Serine/threonine-protein kinase BRSK1
:  BR serine/threonine-protein kinase 1 brain-selective kinase 1 brain-specific serine/threonine-protein kinase 1 hSAD1 KIAA1811 protein kinase SAD1A SAD1 homolog SAD1 kinase SadB kinase short isoform serine/threonine-protein kinase SAD-B synapses of Amphids Defective homolog 1 More... Less...
Ordering Information
Between 728 and 778