ARNT Antibody

Aryl hydrocarbon receptor nuclear translocator (ARNT) is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. ARNT forms a complex with the ligand-bound Ah receptor, and is required for receptor function. ARNT has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia [taken from NCBI Entrez Gene (GeneID: 405)].
ARNT
aryl hydrocarbon receptor nuclear translocator
Aryl hydrocarbon receptor nuclear translocator
:  ARNT protein bHLHe2 class E basic helix-loop-helix protein 2 dioxin receptor, nuclear translocator HIF1B HIF1BETA HIF-1beta HIF-1-beta HIF1-beta hypoxia-inducible factor 1, beta subunit Hypoxia-inducible factor 1-beta TANGO
Product
Specifications
Ordering Information
Human
IP, IHC-P
Between 1 and 50
$339
$99
Human
IP, IHC-P
Between 575 and 625
$339
$99
Human
WB, IP, IHC-P
Includes: 1 each of A302-764A and A302-765A
$472
Includes: 1 each of A302-764A and A302-765A