ADAMTS13 is part of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family that is responsible for cleaving von Willebrand Factor (vWF). ADAMTS13 is synthesized in the liver and secreted to the plasma. A deficiency of the ADAMTS13 protease activity results in unusually larger multimers of vWF and is associated with thrombotic thrombocytopenic purpura.
A disintegrin and metalloproteinase with thrombospondin motifs 13
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13•
ADAM metallopeptidase with thrombospondin type 1 motif, 13•
von Willebrand factor-cleaving protease•
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