Sin1 Antibody

Stress-activated map kinase-interacting protein 1 (Sin1) is highly similar to the yeast stress- activated protein kinase SIN1. Sin1 is an essential mTORC2 subunit that is required to act as the PDK2 that phosphorylates Akt/PKB at Ser 473. Sin1 has been implicated as a scaffolding protein. Sin1 is required for rictor binding in the mTORC2 complex. Sin1 has also been shown to be important to the SAPK (stress-activated kinase) signaling pathway and in the nucleus may act as a scaffold between ATF-2 and p38 to facilitate p38-induced phosphorylation of ATF-2. Sin1 is also found to form a complex with c-Jun N-terminal kinase (JNK) and may similarly function as a scaffolding protein in JNK signaling.
mitogen-activated protein kinase associated protein 1
Target of rapamycin complex 2 subunit MAPKAP1
:  JC310 MEKK2-interacting protein 1 MIP1 mitogen-activated protein kinase 2-associated protein 1 mSIN1 ras inhibitor MGC2745 SAPK-interacting protein 1 SIN1 SIN1b SIN1g stress-activated map kinase interacting protein 1 Stress-activated map kinase-interacting protein 1 stress-activated protein kinase-interacting 1 target of rapamycin complex 2 subunit MAPKAP1 TORC2 subunit MAPKAP1 More... Less...
Ordering Information
between 470 and C-term
Human, Mouse
Between 470 and C-term