SETDB1 (SET domain, bifurcated 1) is a member of the SET (SuVar3-9, enhancer of Zeste, Trithorax) domain-containing protein family that functions as a histone and DNA methyltransferase. SETDB1 was identified through its interaction with ERG (ets-related gene) and KAP1 (KRAB-associated protein1) and was later demonstrated to interact with HDAC1/2 (histone deacetylase 1/2), DNA methyltransferase 3s (DNMT3s), mSin3A/3B, HP1, and MBD1. SETDB1 is suggested to play a role in transcriptional repression important to early development.
ERG-associated protein with a SET domain, ESET•
ERG-associated protein with SET domain•
histone H3-K9 methyltransferase 4•
histone-lysine N-methyltransferase, H3lysine-9 specific 4•
lysine N-methyltransferase 1E•
SET domain bifurcated 1•
SET domain, bifurcated 1•
tudor domain containing 21•More...Less...