PSMB8/LMP7 Antibody

Proteasomes are distributed throughout eukaryotic cells and cleave peptides in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The gene PSMB8 (aka LMP7) encodes a member of the proteasome B-type family, proteasome subunit beta type-8, that is a 20S core beta subunit. Expression of PSMB8/LMP7 is induced by gamma interferon and the PSMB8 gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Nakajo syndrome, an autosomal recessive autoinflammatory disorder, is caused by mutations to PSMB8 [taken from NCBI Entrez Gene (Gene ID: 5696) and UniProtKB (Entry: P28062)].
proteasome subunit beta 8
Proteasome subunit beta type-8
:  ALDD D6S216 D6S216E JMP LMP7 low molecular mass protein 7 low molecular weight protein 7 macropain subunit C13 multicatalytic endopeptidase complex subunit C13 NKJO PRAAS1 protease component C13 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) proteasome catalytic subunit 3i proteasome component C13 proteasome subunit beta 5i proteasome subunit beta type-8 Proteasome subunit beta-5i proteasome subunit Y2 proteasome-related gene 7 PSMB5i really interesting new gene 10 protein RING10 More... Less...
Ordering Information
Between 226 and 276
Between 125 and 175
Includes: 1 each of A305-195A and A305-229A