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PHD3 Antibody

PHD3 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
egl-9 family hypoxia inducible factor 3
Egl nine homolog 3
:  egl nine homolog 3 egl nine-like protein 3 isoform HIFP4H3 HIFPH3 HIF-PH3 HIF-prolyl hydroxylase 3 HPH-1 HPH-3 hypoxia-inducible factor prolyl hydroxylase 3 PHD3 prolyl hydroxylase domain-containing protein 3
Ordering Information
Human, Mouse
between 50 and 100